Article
Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice.
Human molecular genetics - 15 Oct 2016
Ishizu Nobutaka, Yui Daishi, Hebisawa Akira, Aizawa Hidenori, Cui Wanpeng, Fujita Yuko, Hashimoto Kenji, Ajioka Itsuki, Mizusawa Hidehiro, Yokota Takanori, Watase Kei
Abstract excerpt
Point mutations in the vacuolar protein sorting 35 gene (VPS35) have been associated with an autosomal dominant form of late-onset Parkinson disease (PARK17), but there has been considerable debate over whether it is caused by a loss- or gain-of-function mechanism and over the intracellular target site of neurotoxicity. To investigate the pathogenesis of PARK17 in vivo, we generated Vps35 D620N knock-in (KI)...
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