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Article

Parkinson's disease-associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy.

Translational neurodegeneration - 15 Jun 2021

Ma Kai Yu, Fokkens Michiel R, Reggiori Fulvio, Mari Muriel, Verbeek Dineke S

Abstract excerpt

BACKGROUND: Mitochondrial dysfunction plays a prominent role in the pathogenesis of Parkinson's disease (PD), and several genes linked to familial PD, including PINK1 (encoding PTEN-induced putative kinase 1 [PINK1]) and PARK2 (encoding the E3 ubiquitin ligase Parkin), are directly involved in processes such as mitophagy that maintain mitochondrial health. The dominant p.D620N variant of vacuolar protein sorting...

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Share to Carbonyl Cyanide m-Chlorophenyl Hydrazone
Share to Membrane Potential, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34127073
DOI: 10.1186/s40035-021-00243-4
PMCID: PMC8204421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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