Article
Mitophagy in cells with mtDNA mutations: being sick is not enough.
Autophagy - 1 Apr 2012
de Vries Rosa L A, Gilkerson Robert W, Przedborski Serge, Schon Eric A
Abstract excerpt
Despite the emergence of autophagy as a key process for mitochondrial quality control, the existence and persistence of pathogenic mtDNA mutations in human disease suggests that the degradation of dysfunctional mitochondria does not occur widely in vivo. During macroautophagy, a double-membraned cup-shaped structure engulfs cytosolic content. This autophagic vesicle then fuses with lysosomes, allowing hydrolytic...
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