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Article

Endosomal Dysfunction in iPSC-Derived Neural Cells from Parkinson’s Disease Patients with VPS35 D620N

2020-09-03

Abstract excerpt

<title>Abstract</title> <p>Mutations in the Vacuolar protein sorting 35 (<italic>VPS35</italic>) gene have been linked to familial Parkinson’s disease (PD), PARK17. VPS35 is a key component of the retromer complex, which plays a central role in endosomal trafficking. However, whether and how VPS35 deficiency or mutation contributes to PD pathogenesis remain unclear. Here, we analyzed human induced pluripotent ste...

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Literature Corpus work
6f89efe4-75c2-5a45-ae3b-a71159eb161f
DOI
10.21203/rs.3.rs-35371/v2
Open publication

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Endosomal Dysfunction in iPSC-Derived Neural Cells from Parkinson’s Disease Patients with VPS35 D620NDOI 10.21203/rs.3.rs-35371/v2
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