The principal <scp>PINK1</scp> and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons

Abstract excerpt

PINK1 and PARKIN are causal genes for hereditary Parkinsonism. Recent studies have shown that PINK1 and Parkin play a pivotal role in the quality control of mitochondria, and dysfunction of either protein likely results in the accumulation of low-quality mitochondria that triggers early-onset familial Parkinsonism. As neurons are destined to degenerate in PINK1/Parkin-associated Parkinsonism, it is imperative to...

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