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Integrative multiomics profiling of cortical brain organoids reveals a druggable alternative splicing program in schizophrenia

2026-07-10

Abstract excerpt

<h4>ABSTRACT</h4> Clozapine (CLZ) is the only available pharmacological option for treatment resistant schizophrenia (TRS), but its use is limited due to adverse drug reactions and potential cytotoxicity. Despite decades of research, the precise mechanisms of action of CLZ in the human brain remain poorly understood. To address this, we derived cortical brain organoids from a large cohort of schizophrenia (SCZ) p...

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Literature Corpus work
8c714e30-78e0-5bde-8c3f-45899c3c14c2
DOI
10.64898/2026.07.06.736738
Open publication

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Integrative multiomics profiling of cortical brain organoids reveals a druggable alternative splicing program in schizophreniaDOI 10.64898/2026.07.06.736738
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