Article

CLOZAPINE-RELATED BRAIN<i>NRN1</i>EXPRESSION PATTERNS ARE ASSOCIATED WITH METHYLATION AND GENETIC VARIANTS IN SCHIZOPHRENIA

2024-11-04

Abstract excerpt

<h4>ABSTRACT</h4> The Neuritin-1 gene ( NRN1 ), involved in neurodevelopment and synaptic plasticity, is associated with schizophrenia (SZ) and related clinical, cognitive, and neuroimaging phenotypes. Additionally, it is one of the most differentially methylated genes in the prefrontal cortex (PFC) in SZ and is responsive to neurotherapeutic agents. We aimed to investigate NRN1 ’s molecular mechanisms in SZ by an...

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Literature Corpus work: 27dc0198-7661-50c6-8f88-3081323b9fd0
DOI: 10.1101/2024.10.29.24315982

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