Article

Sequestration of TDP-43 <sup>216-414</sup> aggregates by cytoplasmic expression of the proSAAS chaperone

2020-04-17

Abstract excerpt

<h4>ABSTRACT</h4> As neurons age, protein homeostasis becomes less efficient, resulting in misfolding and aggregation. Chaperone proteins perform vital functions in the maintenance of cellular proteostasis, and chaperone-based therapies that promote sequestration of toxic aggregates may prove useful in blocking the development of neurodegenerative disease. We previously demonstrated that proSAAS, a small secreted...

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Literature Corpus work: 8c5cc3f5-dcdc-5154-98b4-81c050812b13
DOI: 10.1101/2020.04.15.039578

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