Article

TDP-43 oligomers detected as initial intermediate species during aggregate formation

2018-12-17

Abstract excerpt

<h4>ABSTRACT</h4> Aggregates of the RNA binding protein TDP-43 are a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which are neurodegenerative disorders with overlapping clinical, genetic and pathological features. Mutations in the TDP-43 gene are causative of ALS, supporting its central role in pathogenesis. The process of TDP-43 aggregation remains poorly understood and whet...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d06db28-542c-567a-94d8-40c25f2eaa79
DOI: 10.1101/499343

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TDP-43 oligomers detected as initial intermediate species during aggregate formationDOI 10.1101/499343Read

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral SclerosisSemantic proximity Read

Phase to Phase with TDP-43.Semantic proximity Read

Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLDSemantic proximity Read

Molecular Mechanisms of Protein Aggregation in ALS-FTD: Focus on TDP-43 and Cellular Protective ResponsesSemantic proximity Read

ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain.Semantic proximity Read

Role and therapeutic potential of liquid-liquid phase separation in amyotrophic lateral sclerosis.Semantic proximity Read

Role of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation.Semantic proximity Read

TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domainSemantic proximity Read

Phase Behavior of TDP-43 and hnRNPH1: From Soluble and Aggregated States to Liquid-Like DropletsSemantic proximity Read

Proteomics Elucidating Physiological and Pathological Functions of TDP-43Semantic proximity Read

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicitySemantic proximity Read

Mechanisms of TDP-43 Proteinopathy Onset and Propagation.Semantic proximity Read