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Article

S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis.

Molecular cell - 4 Jun 2026

Xu Wentao, Li Huina, Zhang Wei, Bai Ge, Shen Chengyong, Zhang Kejing

Abstract excerpt

TDP43 inclusion bodies are widely present in the majority of patients with familial and sporadic amyotrophic lateral sclerosis (ALS). The mechanisms regulating TDP43 solubility remain incompletely understood. Here, we report that TDP43 undergoes S-acylation primarily at the Cys244 residue by the S-acyltransferase zDHHC23. This S-acylation maintains the liquid-like properties of TDP43 by reducing the aberrant...

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Identifiers

PMID: 42127907
DOI: 10.1016/j.molcel.2026.04.016

Genes

PARP1
SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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