Article

Ciliary ARL13B drives renal cystogenesis via its GEF activity

2025-11-21

Abstract excerpt

<h4>Background</h4> Polycystic kidney disease (PKD) is the leading genetic cause of renal failure, resulting in the accumulation of fluid filled cysts and gross enlargement of the kidney. Mutations in PKD1 or PKD2 , which encode ciliary polycystin proteins, are the most common cause of PKD. These proteins function in a cilia-dependent cyst activation (CDCA) pathway–one that requires cilia for its pro-cystic fun...

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Literature Corpus work: 8c35c286-f447-5c29-acb4-5de9cae212cb
DOI: 10.1101/2025.11.20.689124

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