Article

Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease

2002-02-15

Abstract excerpt

The congenital polycystic kidney (cpk) mutation is the most extensively characterized mouse model of polycystic kidney disease (PKD). The renal cystic disease is fully expressed in homozygotes and is strikingly similar to human autosomal recessive PKD (ARPKD), whereas genetic background modulates the penetrance of the corresponding defect in the developing biliary tree. We now describe the positional cloning, muta...

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Literature Corpus work: 0cb21e93-4c4f-5f90-9daf-7027a54ee3c9
DOI: 10.1172/jci0214099

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