Article

Glis3 is a modifier of cyst progression in autosomal dominant polycystic kidney disease

2025-06-09

Abstract excerpt

<h4>Background</h4> Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations affecting polycystin-1 (PC1) or -2 (PC2). The existence of a ‘cilia-dependent cyst activation’ (CDCA) pathway has been identified by demonstrating that structurally intact primary cilia are crucial for cyst growth following loss of polycystins. We previously used translating ribosome affinity purification (TRAP) RNA-Se...

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Literature Corpus work: 0740928f-2cf6-5394-8c77-f2684ca0b350
DOI: 10.1101/2025.06.08.658051

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