Article

Hedgehog signaling is non-cell autonomously activated in the cystic kidney of <i>Arl13b</i> mutant mice

2022-03-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Polycystic kidney disease (PKD) is a ciliopathy characterized by fluid-filled epithelial cysts in the kidney. Although it is well established that the primary cilium is essential for Hedgehog (HH) signalling and HH signalling is abnormally activated in cystic kidneys of multiple PKD models, the mechanism and function of HH activation in PKD pathogenesis remains incompletely...

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Literature Corpus work: 4e102949-1f09-5143-a8bf-34dbd7686bf9
DOI: 10.1101/2022.02.28.482403

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