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Article

mTOR signaling in polycystic kidney disease.

Trends in molecular medicine - 1 Nov 2011

Ibraghimov-Beskrovnaya Oxana, Natoli Thomas A

Abstract excerpt

Polycystic kidney diseases (PKDs) comprise a large group of genetic disorders characterized by formation of cysts in the kidneys and other organs, ultimately leading to end-stage renal disease. Although PKDs can be caused by mutations in different genes, they converge on a set of common molecular mechanisms involved in cystogenesis and ciliary dysfunction, and can be qualified as ciliopathies. Recent advances in...

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PMID: 21775207
DOI: 10.1016/j.molmed.2011.06.003

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