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Article

Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts.

Journal of the American Society of Nephrology : JASN - 1 Dec 2016

Li Yuanyuan, Tian Xin, Ma Ming, Jerman Stephanie, Kong Shanshan, Somlo Stefan, Sun Zhaoxia

Abstract excerpt

The gene for ADP ribosylation factor-like GTPase 13B (Arl13b) encodes a small GTPase essential for cilia biogenesis in multiple model organisms. Inactivation of arl13b in zebrafish leads to a number of phenotypes indicative of defective cilia, including cystic kidneys. In mouse, null mutation in Arl13b results in severe patterning defects in the neural tube and defective Hedgehog signaling. Human mutations of...

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Identifiers

PMID: 27153923
DOI: 10.1681/ASN.2015091004
PMCID: PMC5118478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts.PMID 27153923Read ↗

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Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome.Semantic proximity Read ↗

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ARL13B regulates Sonic hedgehog signaling from outside primary cilia.Semantic proximity Read ↗

Hedgehog signaling is non-cell autonomously activated in the cystic kidney of <i>Arl13b</i> mutant miceSemantic proximity Read ↗

Esrrγa regulates nephron development and ciliogenesis by controlling prostaglandin synthesis and cooperation with Ppargc1aSemantic proximity Read ↗

Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in Mouse Polycystic Kidney DiseaseSemantic proximity Read ↗

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