Article

Causal modeling of gene effects from regulators to programs to traits: integration of genetic associations and Perturb-seq

2025-01-24

Abstract excerpt

<h4> Abstract </h4> Genetic association studies provide a unique tool for identifying causal links from genes to human traits and diseases. However, it is challenging to determine the biological mechanisms underlying most associations, and we lack genome-scale approaches for inferring causal mechanistic pathways from genes to cellular functions to traits. Here we propose new approaches to bridge this gap by comb...

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Literature Corpus work: 7f8916c2-5b9d-50ed-96a5-40c62b001d60
DOI: 10.1101/2025.01.22.634424

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