Article

Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2

2023-11-21

Abstract excerpt

<title>Abstract</title> <p>Sphingosine-1-phosphate (S1P) is a signaling lysolipid critical to heart development, immunity, and hearing. Accordingly, mutations in the S1P transporter SPNS2 are associated with reduced white cell count and hearing defects. SPNS2 also exports the S1P-mimicking FTY720-P (Fingolimod) and thereby is central to the pharmacokinetics of this drug when treating multiple sclerosis. Here, we...

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Literature Corpus work: 8c2c68c3-6cfd-526e-848b-c7dbee92e4a2
DOI: 10.21203/rs.3.rs-3616536/v1

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