Article

Neurodegenerative disorders reversed by ATP13A2 flipping sphingomyelin across lysosome

2025-03-18

Abstract excerpt

<title>Abstract</title> <p>Neurodegenerative disorders involve ATP13A2 gene mutations in Parkinson’s disease (PD), Kufor-Rakeb syndrome (KRS), spastic paraplegia (SPG), neuronal ceroid lipofuscinosis (NCL), and amyotrophic lateral sclerosis (ALS). Here, we report that the P-type ATPase transporter ATP13A2 (PARK9) transports sphingomyelin (SM) across the lysosomal membrane for recycling to the cell membrane, by an...

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Literature Corpus work: 80e67dc4-b9c6-5f09-a0b8-7575d7858d53
DOI: 10.21203/rs.3.rs-6008074/v1

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