Article

Mechanistic insights into transport models of the sphingolipid transport protein, Spinster homolog 2 (Spns2), using MD simulations

2024-03-12

Abstract excerpt

Sphingosine-1-phosphate (S1P) is a sphingolipid signaling molecule that when elevated results in multiple disease states including metastatic cancers. Modulating the extracellular concentrations of S1P has been an evolving strategy in drug development for metastatic cancers due to its role in angiogenesis and cell migration. Research has shown that Spns2, the S1P transport protein, is an important microenvironment...

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Literature Corpus work: 91ca3188-23c6-5a9e-87b1-a0f5ca4237b0
DOI: 10.1101/2024.03.10.584301

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