Article
Structure and mechanism of blood-brain-barrier lipid transporter MFSD2A.
Nature - 1 Aug 2021
Wood Chase A P, Zhang Jinru, Aydin Deniz, Xu Yan, Andreone Benjamin J, Langen Urs H, Dror Ron O, Gu Chenghua, Feng Liang
Abstract excerpt
MFSD2A is a sodium-dependent lysophosphatidylcholine symporter that is responsible for the uptake of docosahexaenoic acid into the brain1,2, which is crucial for the development and performance of the brain3. Mutations that affect MFSD2A cause microcephaly syndromes4,5. The ability of MFSD2A to transport lipid is also a key mechanism that underlies its function as an inhibitor of transcytosis to regulate the...
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