Article

Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2

2024-04-29

Abstract excerpt

<title>Abstract</title> <p>Nearly all lysosomal enzymes reach the lysosome via the mannose-6-phosphate receptor pathway. One of the few known exceptions is the enzyme β-glucocerebrosidase (GCase) that requires the lysosomal integral membrane protein type-2 (LIMP-2) as a proprietary lysosomal transporter. Genetic variations in the GCase encoding gene GBA1 are the cause of Gaucher’s disease (GD) and the highest gen...

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Literature Corpus work: 5a44ff0f-d0d6-54d8-adc5-712af52d8bff
DOI: 10.21203/rs.3.rs-4330358/v1

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