Article

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

2019-03-14

Abstract excerpt

<h4>Summary</h4> The L-type amino acid transporter 1 (LAT1) transports large neutral amino acids and drugs across the plasma membrane and is crucial for nutrient uptake, brain drug delivery and tumor growth. LAT1 is a unique solute carrier that forms a disulfide-linked heterodimer with the cell-surface glycoprotein CD98 heavy chain (CD98hc), but the mechanisms of its molecular assembly and amino acid transport ar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 99c3264b-6fbc-5089-9e86-e7eedaa0b9ea
DOI: 10.1101/577551

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hcDOI 10.1101/577551Read

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hcSemantic proximity Read

Structural basis for amino acid exchange by a human heteromeric amino acid transporterSemantic proximity Read

Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81.Semantic proximity Read

Molecular mechanism of thyroxine transport by monocarboxylate transportersSemantic proximity Read

Structural insights into thyroid hormone transporter MCT8Semantic proximity Read

Structural basis of substrate transport and drug recognition by the human thiamine transporter SLC19A3Semantic proximity Read

Structural insights into cholesterol sensing by the LYCHOS-mTORC1 pathwaySemantic proximity Read

Integrative structural analysis of the human endosomal Na⁺/H⁺ exchanger NHE6 reveals a lipid-stabilized intracellular gate and a disordered C-terminusSemantic proximity Read

The Heavy Chain 4F2hc Modulates the Substrate Affinity and Specificity of the Light Chains LAT1 and LAT2Semantic proximity Read

Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3Semantic proximity Read

Deciphering molecular determinants of GPCR-G protein receptor interactions by complementary integrative structural biology methodsSemantic proximity Read

Molecular basis for ligand-gating of the human GluD1 receptorSemantic proximity Read