Article

Genetic regulation of<i>TERT</i>splicing contributes to reduced or elevated cancer risk by altering cellular longevity and replicative potential

2024-11-05

Abstract excerpt

<h4>ABSTRACT</h4> The chromosome 5p15.33 region, which encodes telomerase reverse transcriptase (TERT), harbors multiple germline variants identified by genome-wide association studies (GWAS) as risk for some cancers but protective for others. We characterized a variable number tandem repeat within TERT intron 6 (VNTR6-1, 38-bp repeat unit) and observed a strong association between VNTR6-1 alleles (Short: 24-27 re...

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Literature Corpus work: 8c2a2442-217b-54a4-9b5e-8670058b8e26
DOI: 10.1101/2024.11.04.24316722

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