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Article

Regulation of human telomerase splicing by RNA:RNA pairing.

Nature communications - 28 Feb 2014

Wong Mandy S, Shay Jerry W, Wright Woodring E

Abstract excerpt

Telomerase adds telomeric repeats onto chromosome ends and is almost universally upregulated in human cancers. Here we demonstrate that RNA:RNA pairing regulates splicing of the catalytic subunit of human telomerase (TERT). Human alleles contain a variable number of 38 bp repeats within TERT intron 6 (>1 kb from exon-intron junctions). At least nine repeats are required for generating the major non-functional...

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Identifiers

PMID: 24577044
DOI: 10.1038/ncomms4306
PMCID: PMC3948165

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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