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Article

Variation at the TERT locus and predisposition for cancer.

Expert reviews in molecular medicine - 18 May 2010

Baird Duncan M

Abstract excerpt

Telomerase and the control of telomere length are intimately linked to the process of tumourigenesis in humans. Here I review the evidence that variation at the 5p15.33 locus, which contains the TERT gene (encoding the catalytic subunit of telomerase), might play a role in the determination of cancer risk. Mutations in the coding regions of TERT can affect telomerase activity and telomere length, and create...

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Source

Identifiers

PMID: 20478107
DOI: 10.1017/S146239941000147X

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variation at the TERT locus and predisposition for cancer.PMID 20478107Read ↗

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Understanding TERT Promoter Mutations: A Common Path to Immortality.Semantic proximity Read ↗

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Human TERT promoter polymorphism rs2853669 is associated with cancers: an updated meta-analysis.Semantic proximity Read ↗

Telomere Maintenance Mechanisms in CancerSemantic proximity Read ↗

Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new playersSemantic proximity Read ↗

Telomere structure and maintenance gene variants and risk of five cancer types.Semantic proximity Read ↗

The TERT rs2736100 polymorphism increases cancer risk: A meta-analysis.Semantic proximity Read ↗

Genetic regulation of<i>TERT</i>splicing contributes to reduced or elevated cancer risk by altering cellular longevity and replicative potentialSemantic proximity Read ↗

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