Article

Type I IFN stimulates lymph node stromal cells from adult and old mice during a West Nile virus infection

2023-01-05

Abstract excerpt

<h4>ABSTRACT</h4> Advanced age is a significant risk factor during viral infection due to an age-associated decline in the immune response. Older individuals are especially susceptible to severe neuroinvasive disease after West Nile virus (WNV) infection. Previous studies have characterized age-associated defects in hematopoietic immune cells during WNV infection that culminate in diminished antiviral immunity. S...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8c144b2d-fcae-5d3a-84a7-08f8b4a4b637
DOI: 10.1101/2023.01.05.522898

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Type I IFN stimulates lymph node stromal cells from adult and old mice during a West Nile virus infectionDOI 10.1101/2023.01.05.522898Read

Aging weakens Th17 cell pathogenicity and ameliorates experimental autoimmune uveitis in miceSemantic proximity Read

Surface phenotype and functionality of WNV specific T cells differ with age and disease severity.Semantic proximity Read

Type I IFN Dynamics Define an Early Checkpoint for Survival and Orchestrate Systemic Neutrophil Heterogeneity in Lethal Viral InfectionSemantic proximity Read

West Nile virus-inclusive single-cell RNA sequencing reveals heterogeneity in the type I interferon response within single cellsSemantic proximity Read

A Temporal and Spatial Atlas of Adaptive Immune Responses in the Lymph Node Following Viral InfectionSemantic proximity Read

Human Lymph Node Cellular Senescence Atlas Reveals Age-Dependent Alteration in Germinal Center B Cell Function and NichesSemantic proximity Read

Key role of T cell defects in age-related vulnerability to West Nile virusSemantic proximity Read

Progenitor and Terminal Subsets of CD8 <sup>+</sup> T Cells Cooperate to Contain Chronic Viral InfectionSemantic proximity Read

Interferon-α and -β subtypes have temporally distinct roles in containing viral spread and protecting vital organs.Semantic proximity Read

Single Cell Analysis of Lung Lymphatic Endothelial Cells and Lymphatic Responses during Influenza InfectionSemantic proximity Read

Repeated In Vivo Stimulation of T and B Cell Responses in Old Mice Generates Protective Immunity against Lethal West Nile Virus EncephalitisSemantic proximity Read

Persistence of virus-specific immune responses in the central nervous system of mice after West Nile virus infection.Semantic proximity Read