Article
Surface phenotype and functionality of WNV specific T cells differ with age and disease severity.
PloS one - 13 Dec 2010
Piazza Paolo, McMurtrey Curtis P, Lelic Alina, Cook Robert L, Hess Rachel, Yablonsky Eric, Borowski Luann, Loeb Mark B, Bramson Jonathan L, Hildebrand William H, Rinaldo Charles R
Abstract excerpt
West Nile virus (WNV) infection can result in severe neuroinvasive disease, particularly in persons with advanced age. As rodent models demonstrate that T cells play an important role in limiting WNV infection, and strong T cell responses to WNV have been observed in humans, we postulated that inadequate antiviral T cell immunity was involved in neurologic sequelae and the more severe outcomes associated with...
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