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Article

Key role of T cell defects in age-related vulnerability to West Nile virus

9 Nov 2009

Abstract excerpt

West Nile virus (WNV) infection causes a life-threatening meningoencephalitis that becomes increasingly more prevalent over the age of 50 and is 40-50x more prevalent in people over the age of 70, compared with adults under the age of 40. In a mouse model of age-related vulnerability to WNV, we demonstrate that death correlates with increased viral titers in the brain and that this loss of virus control with age...

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PMID: 19901080
DOI: 10.1084/jem.20090222

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