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Article

Aging weakens Th17 cell pathogenicity and ameliorates experimental autoimmune uveitis in mice

8 Nov 2021

Abstract excerpt

Aging-induced changes in the immune system are associated with a higher incidence of infection and vaccination failure. Lymph nodes, which filter the lymph to identify and fight infections, play a central role in this process. However, careful characterization of the impact of aging on lymph nodes and associated autoimmune diseases is lacking. We combined single-cell RNA sequencing (scRNA-seq) with flow cytometry...

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PMID: 34748200
DOI: 10.1007/s13238-021-00882-3

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