Article

Interferon-α and -β subtypes have temporally distinct roles in containing viral spread and protecting vital organs.

2026-04-08

Abstract excerpt

<title>Abstract</title> <p>Type I interferons (IFN-Is), including a single IFN-β and over a dozen IFN-αs, induce the anti-viral state. In vitro, IFN-β transcription requires the assembly of the “enhanceosome” composed of the constitutive transcription factors NF-κB and AP-1, and either constitutive IRF3 or IFN-I-inducible IRF7. IRF3 and IRF7 transcribe mouse IFN-α4 and human IFN-α1/13. Only IRF7 transcribes other...

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Literature Corpus work: be30ba86-1840-53fc-aec6-9e1bf94f1ffc
DOI: 10.21203/rs.3.rs-9077466/v1

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