Article

Sex-dependent control of renal tubular homeostasis and stress tolerance by KDM6A

2026-07-24

Abstract excerpt

<h4>ABSTRACT</h4> Biological sex is an important determinant of kidney disease susceptibility and outcomes. The epigenetic modifier KDM6A is an X chromosome-expressed lysine demethylase and molecular scaffold that escapes X chromosome inactivation. Here, we compared the effects of deletion of KDM6A from kidney tubule epithelial cells in female and male mice (KDM6A TubKO ). Knockout of KDM6A from tubule cells agg...

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Literature Corpus work: 7f92ab69-f920-54b2-89de-7cfd5edcc7fc
DOI: 10.64898/2026.07.22.740137

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