Article

DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors

2020-03-09

Abstract excerpt

Fertility across metazoa requires the germline-specific DAZ family of RNA-binding proteins. Here we examine whether DAZL directly regulates progenitor spermatogonia using a conditional genetic mouse model and in vivo biochemical approaches combined with chemical synchronization of spermatogenesis. We find that the absence of Dazl impairs both expansion and differentiation of the spermatogonial progenitor populat...

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Literature Corpus work: 7a024006-082b-5722-9401-9070b41f9418
DOI: 10.1101/2020.03.08.982769

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