Article
DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors
20 Jul 2020
Abstract excerpt
Fertility across metazoa requires the germline-specific DAZ family of RNA-binding proteins. Here we examine whether DAZL directly regulates progenitor spermatogonia using a conditional genetic mouse model and in vivo biochemical approaches combined with chemical synchronization of spermatogenesis. We find that the absence of Dazl impairs both expansion and differentiation of the spermatogonial progenitor...
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