Article

Hif-1α stabilisation polarises macrophages via cyclooxygenase/prostaglandin E2 <i>in vivo</i>

2019-02-01

Abstract excerpt

Macrophage subtypes are poorly characterised in disease systems in vivo . The initial innate immune response to injury and infectious stimuli through M1 polarisation is important for the outcome of disease. Appropriate macrophage polarisation requires complex coordination of local microenvironmental cues and cytokine signalling to influence immune cell phenotypes. If the molecular mechanisms behind macrophage pol...

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Literature Corpus work: 8be8d591-9a31-569c-9eaf-87690a30185c
DOI: 10.1101/536862

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