Article
Temporal control of macrophage pro-inflammatory phenotype by a biphasic HIF-1α regulatory program.
Molecular cell - 20 Aug 2026
Davanzo Gustavo Gastão, Ribeiro Guilherme, Dos-Santos Douglas, Berçot Marcelo Rodrigues, Zaidan Isabella, Menezes Dos Reis Larissa, Virgilio-da-Silva João Victor, Castelucci Bianca Gazieri, Estevão Paulo, Souza Wanderson Dourado, Bruneta Henver S, Fachi José Luis, Costa Webster Leonardo, Andrade João Nilton Barreto, Profeta Gerson S, Dias Rodrigo Requião, Wassano Natália S, de Brito Monteiro Lauar, Aparecida da Silva Pereira Jessica, Favero de Aguiar Cristhiane, Cruz Angelim Monara Kaélle Sérvulo, Santos Wilias Greison, Carregari Victor Corasolla, Peña Jonathan, de Carvalho Fraga Carlos Alberto, Mori Marcelo A, Consonni Silvio Roberto, Martins-de-Souza Daniel, Vinolo Marco Aurélio Ramirez, Nakaya Helder, Murray Peter J, Beheshti Afshin, Cunha Larissa Dias, Moraes-Vieira Pedro M
Abstract excerpt
Hypoxia-inducible factor 1α (HIF-1α) broadly orchestrates metabolic reprogramming in inflammatory macrophages. However, how HIF-1α shapes the earliest events following activation of pattern recognition receptors and triggers inflammatory responses remain unclear. We found that HIF-1α is functionally active shortly after macrophage inflammatory stimulation via a Rubicon (RUBCN)-NADPH oxidase (NOX2) reactive oxygen...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.