Retargeting: an unrecognized consideration in endonuclease-based gene drive biology

Abstract excerpt

There is intense interest surrounding the use of gene editing nucleases in gene drive systems to control agricultural insect pests and insect vectors of infectious diseases such as malaria, dengue and Zika virus. While gene drive systems offer immense promise for the beneficial modification of deleterious insect populations, their unique mechanism of action also raises novel safety concerns and regulatory issues....

Topics

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• Clustered Regularly Interspaced Short Palindromic Repeats
• CRISPR-Associated Proteins
• CRISPR-Cas Systems
• Gene Editing
• Gene Expression Regulation, Plant
• Plants, Genetically Modified
• Risk Assessment
• RNA, Guide, CRISPR-Cas Systems

Identifiers and source

Literature Corpus work

8bbff055-22b3-5a56-9d5d-444ece251391

DOI

10.1101/089946