Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes.

doi:10.1016/j.celrep.2020.107925

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Article

Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes.

Cell reports - 21 Jul 2020

Feyen Dries A M, McKeithan Wesley L, Bruyneel Arne A N, Spiering Sean, Hörmann Larissa, Ulmer Bärbel, Zhang Hui, Briganti Francesca, Schweizer Michaela, Hegyi Bence, Liao Zhandi, Pölönen Risto-Pekka, Ginsburg Kenneth S, Lam Chi Keung, Serrano Ricardo, Wahlquist Christine, Kreymerman Alexander, Vu Michelle, Amatya Prashila L, Behrens Charlotta S, Ranjbarvaziri Sara, Maas Renee G C, Greenhaw Matthew, Bernstein Daniel, Wu Joseph C, Bers Donald M, Eschenhagen Thomas, Metallo Christian M, Mercola Mark

Abstract excerpt

Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have enormous potential for the study of human cardiac disorders. However, their physiological immaturity severely limits their utility as a model system and their adoption for drug discovery. Here, we describe maturation media designed to provide oxidative substrates adapted to the metabolic needs of human iPSC (hiPSC)-CMs. Compared with...

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Identifiers

PMID: 32697997
DOI: 10.1016/j.celrep.2020.107925
PMCID: PMC7437654

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