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Article

Human perinatal stem cell derived extracellular matrix enables rapid maturation of hiPSC-CM structural and functional phenotypes.

Scientific reports - 4 Nov 2020

Block Travis, Creech Jeffery, da Rocha Andre Monteiro, Marinkovic Milos, Ponce-Balbuena Daniela, Jiménez-Vázquez Eric N, Griffey Sy, Herron Todd J

Abstract excerpt

The immature phenotype of human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) is a major limitation to the use of these valuable cells for pre-clinical toxicity testing and for disease modeling. Here we tested the hypothesis that human perinatal stem cell derived extracellular matrix (ECM) promotes hiPSC-CM maturation to a greater extent than mouse cell derived ECM. We refer to the human ECM as...

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Identifiers

PMID: 33149250
DOI: 10.1038/s41598-020-76052-y
PMCID: PMC7643060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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