Article

Enhanced iPSC Cardiomyocyte Maturation via Combined 3D-Culture and Metabolic Cues

2025-10-30

Abstract excerpt

Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) have become an invaluable tool for disease modelling and drug testing. However, while many etiologies of heart failure involve defects in excitation-contraction coupling, mitochondrial energetics or both, iPSC-CM are limited by the developmental immaturity of these processes. Here, we report a combinatorial strategy to enhance the maturation of h...

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Literature Corpus work: ed2b2a1b-7f2f-555e-880a-1ad4597eb5c4
DOI: 10.1101/2025.10.29.684362

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