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Adult human heart extracellular matrix improves human iPSC-CM function via mitochondrial and metabolic maturation

25 Jan 2025

Abstract excerpt

Myocardial infarction can lead to the loss of billions of cardiomyocytes, and while cell-based therapies are an option, immature nature of in vitro-generated human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iCMs) is a roadblock to their development. Existing iPSC differentiation protocols don't go beyond producing fetal iCMs. Recently, adult extracellular matrix (ECM) was shown to retain tissue...

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PMID: 39862185
DOI: 10.1093/stmcls/sxaf005

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