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Article

Association of atrial fibrillation susceptibility genes, atrial fibrillation phenotypes and response to catheter ablation: a gene-based analysis of GWAS data.

Journal of translational medicine - 5 Apr 2017

Husser Daniela, Büttner Petra, Ueberham Laura, Dinov Borislav, Sommer Philipp, Arya Arash, Hindricks Gerhard, Bollmann Andreas

Abstract excerpt

BACKGROUND: Previous studies have suggested PITX2, KCNN3 and ZFHX3 as atrial fibrillation (AF) susceptibility genes. Single common genetic polymorphisms of those genes have been linked with AF phenotypes and rhythm outcome of AF catheter ablation although their mechanisms remain elusive. New gene-based association tests may help clarifying genotype-phenotype correlations. Therefore, we hypothesized that PITX2,...

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Topics

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Share to Atrial Fibrillation
Share to Catheter Ablation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PITX2 gene

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Share to Recurrence

Source

Open in PubMed Open full text

Identifiers

PMID: 28381281
DOI: 10.1186/s12967-017-1170-3
PMCID: PMC5381139

Genes

ZFHX3
KCNN3
PITX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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