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Article

A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network

8 Jan 2024

Abstract excerpt

BACKGROUND: The relationship between heart failure (HF) and atrial fibrillation (AF) is clear, with up to half of patients with HF progressing to AF. The pathophysiological basis of AF in the context of HF is presumed to result from atrial remodeling. Upregulation of the transcription factor FOG2 (friend of GATA2; encoded by ZFPM2 ) is observed in human ventricles during HF and causes HF in mice. METHODS: FOG2...

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Share to Atrial Fibrillation Management and Outcomes
Share to Cardiac electrophysiology and arrhythmias
Share to Congenital heart defects research

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Identifiers

PMID: 38189150
DOI: 10.1161/circulationaha.123.066804

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