Article

Nutrient Sensing Receptor GPRC6A Regulates mTORC1 Signaling and Tau Biology

2024-03-27

Abstract excerpt

Tauopathies, including Alzheimer’s disease (AD), comprise microtubule-associated protein tau aggregates that cause neuronal cell death and clinical cognitive decline. Reducing overall tau abundance remains a central strategy for therapeutics; however, no disease-modifying treatment exists to date. One principal pathway for balancing cellular proteostasis includes the mechanistic target of rapamycin complex 1 (mTOR...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1113e822-6ecf-550a-befe-5b198bb7ea37
DOI: 10.1101/2024.03.24.586459

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nutrient Sensing Receptor GPRC6A Regulates mTORC1 Signaling and Tau BiologyDOI 10.1101/2024.03.24.586459Read

Spatially and Functionally Distinct mTORC1 Entities Orchestrate the Cellular Response to Amino Acid AvailabilitySemantic proximity Read

Molecular neurobiology of mTORSemantic proximity Read

mTOR signaling as a molecular target for the alleviation of Alzheimer's disease pathogenesisSemantic proximity Read

Systemic Actions of SGLT2 Inhibition on Chronic mTOR Activation as a Shared Pathogenic Mechanism between Alzheimer’s Disease and DiabetesSemantic proximity Read

Amino Acid Transporters Are a Vital Focal Point in the Control of mTORC1 Signaling and Cancer.Semantic proximity Read

The Metabolic Basis for Nervous System Dysfunction in Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s DiseaseSemantic proximity Read

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.Semantic proximity Read

The mechanistic target of rapamycin (mTOR) and the silent mating-type information regulation 2 homolog 1 (SIRT1): oversight for neurodegenerative disordersSemantic proximity Read

A PTER-dependent pathway of taurine metabolism linked to energy balanceSemantic proximity Read

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.Semantic proximity Read

Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.Semantic proximity Read

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegenerationSemantic proximity Read