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Article

Is the urea cycle involved in Alzheimer's disease?

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Hansmannel Franck, Sillaire Adeline, Kamboh M Ilyas, Lendon Corinne, Pasquier Florence, Hannequin Didier, Laumet Geoffroy, Mounier Anais, Ayral Anne-Marie, DeKosky Steven T, Hauw Jean-Jacques, Berr Claudine, Mann David, Amouyel Philippe, Campion Dominique, Lambert Jean-Charles

Abstract excerpt

Since previous observations indicated that the urea cycle may have a role in the Alzheimer's disease (AD) process, we set out to quantify the expression of each gene involved in the urea cycle in control and AD brains and establish whether these genes could be genetic determinants of AD. We first confirmed that all the urea cycle enzyme genes are expressed in the AD brain. The expression of arginase 2 was greater...

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Identifiers

PMID: 20693631
DOI: 10.3233/JAD-2010-100630
PMCID: PMC2945690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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