Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Apr 2015

Kan Matthew J, Lee Jennifer E, Wilson Joan G, Everhart Angela L, Brown Candice M, Hoofnagle Andrew N, Jansen Marilyn, Vitek Michael P, Gunn Michael D, Colton Carol A

Abstract excerpt

The pathogenesis of Alzheimer's disease (AD) is a critical unsolved question; and although recent studies have demonstrated a strong association between altered brain immune responses and disease progression, the mechanistic cause of neuronal dysfunction and death is unknown. We have previously described the unique CVN-AD mouse model of AD, in which immune-mediated nitric oxide is lowered to mimic human levels,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Arginine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunologic Factors

Share to Maze Learning

Share to Memory, Short-Term

Share to Microarray Analysis

Share to Microglia

Share to Nitric Oxide Synthase Type II

Source

Open in PubMed Open full text

Identifiers

PMID: 25878270
DOI: 10.1523/JNEUROSCI.4668-14.2015
PMCID: PMC4397598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.PMID 25878270Read ↗

L-norvaline reverses cognitive decline and synaptic loss in a murine model of Alzheimer’s diseaseSemantic proximity Read ↗

Myeloid Arginase 1 Insufficiency Exacerbates Amyloid-β Associated Neurodegenerative Pathways and Glial Signatures in a Mouse Model of Alzheimer's Disease: A Targeted Transcriptome Analysis.Semantic proximity Read ↗

mNos2 deletion and human NOS2 replacement in Alzheimer disease models.Semantic proximity Read ↗

Systemic inflammation and Alzheimer's disease.Semantic proximity Read ↗

The Role of Macrophage Migration Inhibitory Factor in Alzheimer′s Disease: Conventionally Pathogenetic or Unconventionally Protective?Semantic proximity Read ↗

The AppNL-G-F mouse model of Alzheimer’s disease is refractory to regulatory T cell treatmentSemantic proximity Read ↗

The <i>App</i> <sup> <i>NL-G-F</i> </sup> mouse model of Alzheimer’s disease is refractory to regulatory T cell treatmentSemantic proximity Read ↗

Arginase Inhibition Supports Survival and Differentiation of Neuronal Precursors in Adult Alzheimer’s Disease MiceSemantic proximity Read ↗

Diverse Inflammatory Responses in Transgenic Mouse Models of Alzheimer’s Disease and the Effect of Immunotherapy on These ResponsesSemantic proximity Read ↗

Suppression of AIMP1 protects cognition in Alzheimer's disease model mice 3xTg-AD.Semantic proximity Read ↗

Ablation of TNF-RI/RII Expression in Alzheimer's Disease Mice Leads to an Unexpected Enhancement of PathologySemantic proximity Read ↗

Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.