Integral roles of a guanine nucleotide exchange factor, FARP2, in osteoclast podosome rearrangements

Abstract excerpt

Podosomes are recently rediscovered highly dynamic actin-rich structural and functional modules that form close contact with the surrounding substrate. They play a role in the control of migration, tissue invasion, and matrix remodeling of highly motile cells, including lymphocytes, macrophages, dendritic cells, and osteoclasts. In osteoclasts, the compaction of podosomes induces the formation of a tight adhesive...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone Metabolism and Diseases
• Share to Cell Adhesion Molecules Research
• Share to NF-κB Signaling Pathways