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Article

Whole-genome screens reveal regulators of differentiation state and context-dependent migration in human neutrophils

18 Sept 2023

Abstract excerpt

Neutrophils are the most abundant leukocyte in humans and provide a critical early line of defense as part of our innate immune system. We perform a comprehensive, genome-wide assessment of the molecular factors critical to proliferation, differentiation, and cell migration in a neutrophil-like cell line. Through the development of multiple migration screen strategies, we specifically probe directed (chemotaxis),...

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PMID: 37723145
DOI: 10.1038/s41467-023-41452-x

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