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Article

PKN2 is essential for mouse embryonic development and proliferation of mouse fibroblasts.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Feb 2017

Danno Sally, Kubouchi Koji, Mehruba Mona, Abe Manabu, Natsume Rie, Sakimura Kenji, Eguchi Satoshi, Oka Masahiro, Hirashima Masanori, Yasuda Hiroki, Mukai Hideyuki

Abstract excerpt

PKN2, a member of the protein kinase N (PKN) family, has been suggested by in vitro culture cell experiments to bind to Rho/Rac GTPases and contributes to cell-cell contact and cell migration. To unravel the in vivo physiological function of PKN2, we targeted the PKN2 gene. Constitutive disruption of the mouse PKN2 gene resulted in growth retardation and lethality before embryonic day (E) 10.5. PKN2-/- embryo did...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28102564
DOI: 10.1111/gtc.12470

Genes

PKN2
PKN1
PKN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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