Article

The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development

2020-06-29

Abstract excerpt

<h4>ABSTRACT</h4> Pluripotent cells of the mammalian embryo undergo extensive chromatin rewiring to prepare for lineage commitment after implantation. Repressive H3K27me3, deposited by Polycomb Repressive Complex 2 (PRC2), is reallocated from large gene-distal blankets in pre-implantation embryos to mark promoters of developmental genes. The factors that mediate this global redistribution of H3K27me3 are unknown....

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Literature Corpus work: 8b458568-ecf4-5d78-9574-c5994d10df48
DOI: 10.1101/2020.06.28.176412

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